Just noticed this project, which is sponsored by Microsoft. Chem4Word aims to:

…simplify the authoring of chemical information in Word – specifically the inclusion of chemical structures. This project will also demonstrate how semantic information can be captured at authoring time as the way to more accurately represent the chemical content, create high quality depictions, contribute to simpler pre-publication processes and richer information discovery scenarios, as well as to preserve chemical information for archival purposes.

We did a similar thing in Lotus Notes ages and ages ago, and it worked really well. I wonder how much of the “I want a chemistry-centric ELN” question this will end up solving (not all of it but it will have some impact I am sure).